Studies on H E R P E T I C Infection in Mice I. Passive Protection against Virus Inoculated Intranasally* by George

I t has been the experience of the present writers that herpes virus given intranasally to 2-week-old mice produces an almost uniformly fatal infection. I t has been found, in addition, that mice born of immune mothers are themselves immune to the virus administered by the intranasal route (1). These findings pose several questions. In the present and subsequent reports, we shall describe investigations of the nature of the immunity conferred upon the progeny of immune mothers, as well as investigations of the nature and pathogenesis of herpetic infection of suckling mice. I t is the purpose in this first paper to report investigations of the nature and mode of acquisition of the immunity exhibited by mice born of immune mothers.